Furthermore, the top-down distribution of vaccines - from the central level to the regions, then to each health district, and then to health centers in proportion to approximate target populations - may worsen the direct impact of wastage on coverage and efficiency.
With modifications to account for increased variance from more complicated lineages, as well as performance modifications to account for increased number of nuclei (discussed below), all of the bottom-up and top-down distributions used in this model have a direct application to other model organism.
From the top down, there is a commitment to the distribution system that is enduring and strong.
Harvard's administration was strictly "top down".
Top, down, starting with hair.
There are many less tangible problems: state-controlled distribution, top-down planning and a quota system that doesn't fully encourage innovation and individual effort.
Is it simply the replacement of existing fuel technologies within the current system of centralised top-down generation, transmission and distribution?
The top-down approach describes the distribution of force and energy on various brain regions, while the bottom-up approach describes effects of the trauma at the micro- and nanoscales.
This contrasts directly with the outcomes associated with either the maintenance of a traditional top-down "big transmission and distribution" model or the development of a market-driven top-down "energy services companies" model, which promote a "high level of passivity from consumers" and actually result in increased projected overall demand and poorer reductions in carbon emissions [43].
Instead, Americans rely on trickle-down distribution.
Meanwhile, some environmentalists, trade unionists and green leaders have supported the development of a proposed top-down "big" generation, transmission and distribution model as a means of meeting renewable targets and the development of a European super grid and for the potential to create economic growth and, by extension, jobs.
