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As noted previously, the OFC has been shown to play a critical role in aggression (Antonucci et al. 2006; Beyer et al. 2014; Mehta and Beer 2010; Grafman et al. 1996; Miczek et al. 2007; Gansler et al. 2011), particularly when there are deficits in the top-down abilities of the OFC related to the inhibition of aggressive impulses (Siever 2008).
A number of investigations have shown that the OFC has been strongly related to aggression as well as emotion dysregulation (Antonucci et al. 2006; Beyer et al. 2014; Mehta and Beer 2010; Grafman et al. 1996; Miczek et al. 2007; Gansler et al. 2011), particularly in instances where there are deficits in the top-down abilities of the OFC to modulate aggressive impulses or urges (Siever 2008).
That's why Fenton says that, boiled down, the consumerization of enterprise is about software companies re-focusing on ease of use and a top-down ability to be flexible and to quickly adopt those always-there consumer tools and technologies.
Top Down, Bottom UP.
Top down, pushing buttons".
Top, down, starting with hair.
Second, the personality trait "harm avoidance", reflecting a proclivity to repress stressful stimuli, may decrease stress resiliency, while increased "self-directedness", reflecting overall top-down self-regulation abilities, may promote stress resiliency [ 72].
Top-down modulation underlies our ability to selectively attend to relevant stimuli and to ignore irrelevant stimuli.
Each residual error model was investigated and assessed under a top-down approach focused on its ability to properly characterize the errors.
Andy Burnham, the shadow health secretary, warned that the government's obsession with "top-down reorganisations" had sapped the ability of the NHS to become more efficient.
New technologies are eliminating those inefficiencies, and, with them, the opportunity for a kind of top-down information arbitrage that is, the ability of a government to benefit itself or powerful special interests at the expense of its people by following policies that would never win their support if they had unfettered access to all relevant information.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com