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Patients either received the top dose of Pfizer's Lipitor or the second-highest dose of Bristol's Pravachol.
A Pfizer -funded study showed the top dose of the company's cholesterol drug Lipitor stopped plaque from accumulating in arteries but did not reverse its buildup.
Patients on the 80 mg top dose of Lipitor had a 22% reduction in cardiovascular events, including heart attacks and strokes.
He used to give Zetia to those at high risk for heart attacks who couldn't get their cholesterol low enough with the top dose of Lipitor or other high-powered drugs.
To find out, Nissen compared the top dose of Lipitor to the second-highest dose of Bristol-Myers Squibb 's Pravachol, the third-best-selling of these cholesterol medicines (known as statins), in as many as 600 patients.
Another study, called ASAP, conducted by some of the same experts who ran ENHANCE, compared the top dose of 80 milligrams of Pfizer's Lipitor with the second-highest dose of Zocor.
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After consuming top doses of Prozac and Wellbutrin for more than four years, I'm proud to say I can once again use a kitchen knife without thinking it may one day be used to stab someone, which is great news but not something to brag about on a dating profile or in my college alumni magazine.
For the 2-year studies, mean body weights of the top dose groups of male rats and of both sexes of mice were lower than those of the controls.
Survivals of the top dose group of rats and mice of each sex were reduced; however, at week 92 for rats and week 91 for mice, survival was greater than 60% in all groups; most of the dosed animals that died before week 103 had neoplasia.
The fit of the model to the data for the top dose group of 420 mg is illustrated in Figure 3.
Whereas the average relative liver weight of top dose animals was 110% of control in negative studies, it was 150% in positive studies.
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Justyna Jupowicz-Kozak
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