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Some experts say that for most patients, as little as one-fourth the standard top dose would work, saving the health care system more than $200,000 a year per Gaucher patient.
Not all doctors are confident in its safety at its top dose.
Patients either received the top dose of Pfizer's Lipitor or the second-highest dose of Bristol's Pravachol.
A Pfizer -funded study showed the top dose of the company's cholesterol drug Lipitor stopped plaque from accumulating in arteries but did not reverse its buildup.
Patients on the 80 mg top dose of Lipitor had a 22% reduction in cardiovascular events, including heart attacks and strokes.
The top dose did a better job preventing strokes than warfarin, cutting the risk of strokes by one-third to 1.1% per year, without increasing bleeding.
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Brain Aβ38 was also significantly lowered at the two top doses and a slight, but significant lowering of 11% was observed for brain Aβ40 levels at the 30 mg/kg dose.
Based on the high mortality rate for the top-dose male and female rat treatment groups, it is plausible that the maximum tolerated dose was exceeded.
(D ) Across the LPS doses tested: top panel, dose-response curve of the fraction of active cells (plotted is the mean of two duplicate cell chambers in the chip for each condition), middle panel, the intensity of nuclear NF-κB at the peak of the response, and lower panel, time until the peak of the response.
Top up doses with graded doses were administered at different intervals after fractionated radiotherapy in order to estimate isoeffective dose levels and calculate the dose needed to counteract repopulation during the interval between fractionated radiotherapy and top up irradiation (with and without MMC).
This effect of MMC was equivalent to 31.7 Gy top up dose.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com