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Samtools (v1.3, http://samtools.sourceforge.net) and Picard tools (version 2.2.2, http://picard.sourceforge.net) were used to build indices and remove duplicates.

3D pc-ASL data, including perfusion weighted images and proton density-weighted images, was processed using Functional tools (version:9.4.05) on GE Advanced Workstation 4.5.

Molecular docking was performed with AutoDock tools (version 4.2.6) with the default setting, based on the Lamarckian Genetic Algorithm (Scripps Research Institute, La Jolla, CA, USA).

Our tests were developed on top of SYS/BIOS using the OpenMP implementation from Texas Instruments, MCSDK version 2.1, and Code Generation Tools version 7.4.1 with OpenMP support enabled.

SNPs were genotyped by the Affymetrix Genotyping Tools Version 2.0 software.

Microarray analysis was done with the SAM module within BRB-Array tools (Version 3.4, NCI).

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The output files were sorted using the picard-tools (version 1.60) SortSam option using the sort order command "coordinate" and Picard-tools CollectInsertSizeMetrics option.

Lerdorf initially announced the release of PHP/FI as "Personal Home Page Tools (PHP Tools) version 1.0" publicly to accelerate bug location and improve the code, on the Usenet discussion group comp.infosystems.www.authoring.cgi on June 8 , 1995

Target protein structures are converted to the required PDBQT format using MGL Tools (version 1.5.4) [31.5.4

Metabolic pathway reconstruction was carried out using Pathway Tools version 14.0 [27] with MetaCyc version 14.1 [28] as a reference database.

All statistical MS data analyses were conducted using ClinPro Tools version 2.2 (Bruker Daltonics) [ 22].

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