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Collections of yeast deletion mutants can be powerful tools: the function of particular genes can be clarified by analyzing the phenotypes of mutants lacking genes of interest; this is known as 'phenomics' [ 16- 20].
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Based on miRSponge data sources and functional annotation tools, the functions of some poorly understood miRNA sponges can be inferred.
The Mercator tool predicts the function of input DNA sequences by searching a variety of reference databases (currently six are available: three BLAST-based, two RPSBLAST-based and InterProScan).
The tetracycline-responsive master clones are potentially powerful tools for studying the function of various genes in postnatal myogenesis.
Recently, aptamers have proven to be valuable tools for modulating the function of endogenous cellular proteins in their natural environment.
Dear Editor, Targeted gene knock-out and knock-in mice are valuable tools for elucidating the function of genes in vivo (Capecchi, 2001).
The new GENASSIST kits, combined with access to rAAV, ZFN, and CRISPR technologies, give researchers an invaluable suite of tools to determine the function of endogenous gene alterations and their effect on disease and therapeutic responses.
Selective modulators of tonically activated receptor are valuable tools for investigating the function of tonic inhibition.
Zebrafish models of angiogenesis have become important tools to examine the function of angiogenic genes in in vivo settings.
Thermosensitive mutants (ts) are very useful tools for studying the function of essential genes (Govindaraghavan et al. 2014).
Dominant negative (dNrab11, rab11S25N) and dominant active (dArab11, rab11Q70L) forms of rab11 are widely used tools for manipulating the function of rab11.
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