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Whereas the earlier inhibitory peptides are highly specific, we believe that peptides targeting additional interactions between PKC and selective substrates will generate even more selective tools that regulate different functions of individual isozymes.
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The recently developed switches.ELM resource (http://switches.elm.eu.org) (78), a database and analysis tool for switching mechanisms that regulate the functions of short linear motifs, and thus the interactions mediated by these interfaces, captures the context-dependency and interdependency of molecular interactions in great detail.
The wealth of genetic information on the function of circadian clocks in many tissues has provided tools to dissect the mechanisms that regulate timing on the molecular, cellular, circuit, and whole organism levels.
For all these reasons, eQTL mapping studies is a new powerful tool to identify genetic variants that regulate gene expression [ 5- 9].
The model serves as an interactive tool to investigate the mechanisms that regulate germ cell arrangement within the seminiferous epithelium and the timing of sperm release.
Accountability mechanisms are governance tools that seek to regulate answerability between the health system and the community (external accountability) and/or between different levels of the health system (bureaucratic accountability).
However, despite the growing collection of tools to disturb the circuit that regulates waking, Drosophila neurogenetics lacks a reliable method to measure the outcome of these manipulations.
I ask that these companies make tools that can help people regulate themselves and curb those addictive tendencies.
As our research deepened, we became involved in the medical community, whose practitioners pointed out that the nine "choices" made by extremely happy people are actually behavioral tools that they use to regulate their own biochemistry in the positive direction, that is, away from feelings of depression and pessimism.
These natural Cas9-specific "anti-CRISPRs" present tools that can be used to regulate the genome engineering activities of CRISPR-Cas9.
In Jacquet's view, shaming is a tool that can effectively regulate harmful acts for which there's no official punishment.
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