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The group tested nearly 200 gardening products, including hoses, gloves, kneeling pads and tools, for lead, cadmium, bromine, chlorine, phthalates and bisphenol A. Over all, they found that two-thirds of the products tested contained levels of one or more chemicals in excess of standards set for other consumer products.
Among many methods developed to date, docking-based techniques are valuable tools for lead identification [4].
Docking methods are powerful in silico tools for lead generation and optimization.
The company also provides tools for lead generation in social sales channels such as Facebook, LinkedIn and Twitter.
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This method could become a useful tool for lead optimization and for designing novel chemical scaffolds that recognize distinct protein structural motifs.
Kramer et al. [18] performed matched molecular pair analysis by comparing the ChEMBL data and Novartis data suggesting that MMP analysis is a very robust tool for lead optimization and will have growing importance in daily medicinal chemistry practice.
In conclusion, we have demonstrated that FINDSITEcomb is an automated, robust and rapid methodology that can identify novel protein-ligand binding interactions that are often in the nM range or better, and which, in combination with appropriate mechanistic studies and biological activity assays can be a promising tool for lead identification/drug discovery.
Clustering analysis provides information about diversity of molecules and thus is an important tool for lead optimization and drug discovery (35, 36).
This is where we see the first glimpse of the startup's business model, as it plans to use its content and textbook marketplace as a tool for lead-gen, grabbing a percentage of each sale when a student purchases a textbook from Amazon or Chegg, for example.
Support vector machines (SVM) and other machine-learning (ML) methods have been explored as ligand-based virtual screening (VS) tools for facilitating lead discovery.
The robustness and external predictive power and applicability domain as the most important parameters of QSAR models shall increase their practical use as reliable virtual screening tools for pharmaceutical lead identification.
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