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It is reported as an effective tool for activation of gene expression also [ 11].
36 The use of chiral (Lewis) bases has emerged as one of the most powerful organocatalytic tools for the activation and control of small organic molecules in highly stereoselective applications.
This switchable activity is unique and may provide a tool for targeted activation of AFP properties in applications such as cryosurgery.
Similarly, UAS constructs of TrpA1 can be used as a tool for thermogenetic activation of neurons for behavioral studies (Hamada et al. 2008).
Moreover, we showed that helper epitope peptide is a good tool for the activation of MAGE-A4-specific Th1 cells to produce Th1 cytokines, which will preferable to activate CTL-mediated antitumour immunity.
To dissect the cellular roles of individual kinases, it is useful to design tools for their selective activation.
Although there are tools for temporally controlled activation such as dTrpA1 or Channelrhodopsin (ChR2) that are well-characterized, we utilized P2X2 receptors for the majority of our experiments.
One of the main problems when studying the role of astrocytes in vitro and in vivo is the lack of suitable tools for their selective activation.
Results of dual phase characterization suggested that xerogel matrix entrapment is a promising tool for hyper-activation and stabilization of LiP making it a valuable and versatile enzyme for various industrial and biotechnological applications.
The inhibitors presented will guide the development of therapeutics targeting C. difficile, and the probes will serve as tools for studying the unique activation mechanism of bacterial toxin CPDs.
While the phosphorylation array represents a useful screening tool to assess tissue samples for activation of key RTKs, it does not detect total protein, and will therefore not give a complete picture as to the extent of tumor RTK expression.
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