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Examples of this plugin application programming interface (API) include the Pipeline-Imaging Data Archive (IDA) interface and the Extensible Neuroimaging Archive Toolkit (XNAT) database [17].

Gene ontology analysis was performed using the AgriGO analysis toolkit and database [ 49].

The WEB-based GEne SeT AnaLysis Toolkit (WebGestalt) database was used for functional characterization and classification of gene symbols harboring high impact variants [ 29].

Candidate genes were submitted to AgriGO (Go analysis toolkit and database for agriculture community) (http://bioinfo.cau.edu.cn/agriGO/index.php) and AgBase (http://www.agbase.msstate.edu/) for gene ontology analysis [ 79].

GO based functional enrichment analysis of drought-tolerant candidate genes was performed by the web-based tools AgriGO (Go analysis toolkit and database for agriculture community) (http://bioinfo.cau.edu.cn/agriGO/index.php) and AgBase (http://www.agbase.msstate.edu/).edu/

To interrogate possible biological processes affected by the Li 2 mutation, parametric analysis of gene set enrichment (PAGE) was performed for microarray data using AGRIgo toolkit and database [ http://bioinfo.cau.edu.cn/agriGO; [ 26].

The toolkit creates databases that contain summarized versions of Wikipediaʼs content and structure, and includes a Java API to provide access to them.

Since the biological toolkits and databases are not complete enough, they would tend to miss transcription factors that are not yet found.

We applied web services technology to wrap the bioinformatics toolkits and databases to automatically extract the promoter regions of DNA sequences and predicted the transcription factors that regulate the gene expressions.

Since the biological toolkits and databases are not complete enough, they would tend to miss transcription factors that are not yet found and it may cause the incompleteness of the inferred interaction networks and thus reduces the recall of the inference method that misses some inferred gene relations.

We extend this model by transplanting a complete scriptable chemical information processing toolkit into a database extension.

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