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For functional studies, a large toolbox exists in zebrafish and medaka: downregulation of gene expression during early development can be achieved by morpholinos, and gene knockout can be mediated by sophisticated genome-editing technologies such as zinc finger nucleases and TALENs.
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In the pharmaceutical industry context, quantitative and systems pharmacology can, therefore, be considered as the framework that provides the full modeling toolbox that exists within quantitative sciences, supporting the model-informed drug discovery and development paradigm.
"It's like having a toolbox I never knew existed," Heche said, holding up a strip of long blond hair dyed to match her own that would be sewn onto a foundation of tiny braids along her scalp.
When a solution to this set of LMIs exists, the parametric matrices of a desired filter can be easily obtained using LMI toolbox.
This toolbox of genetic parts previously did not exist for the industrially promising cyanobacterium, Synechococcus sp. strain PCC 7002.
This toolbox use kmeans, agnes, fuzzy cmeans algorithms that are exist in MATLAB software and available web interface for the evaluate clustering results with cluster validity criteria.
The toolbox can be easily extended.
Efficient implementations of LARS exist in various programming languages including R (lars package, [ 24]) and MATLAB (SPAMS toolbox, [ 32]).
The metabolic network reconstruction process is becoming more advanced, and there now exist various tools for semi-automatic model inference, e.g., PathwayTools [ 13], the RAVEN toolbox [ 14], KEGGtranslator [ 15], CoReCo [ 16], SuBliMinaL [ 17] (see [ 18] for a review).
Based on thesecriteria, possible candidate tools exist and may include the GlobalEnvironmental Management Initiative (GEMI) Metrics Navigator [72], measuring impact framework [73], or socio-economic assessment toolbox (SEAT) [74].
Besides this pattern possibly being the ancestral spiralian condition, there may exist 'universal constraints' on the functionally optimal neuromuscular design when being of microscopic size and with limited cell number, and given the evolutionary toolbox within Spiralia.
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