To see why, consider again Henrich's (2004) tool-loss model, discussed in the previous section.
Given the diversity of applications, amendments and attacks, a full evaluation of the disciplinary relevance of the Tasmanian tool-loss model shall not be attempted here.
12 A selection of recent related work directly speaks in favour of the (multi-) disciplinary relevance of Henrich's "Tasmanian tool-loss" model.
Recently, we developed a method of dsRNA-injectable RNAi as a tool for loss-of-function studies in adult Drosophila (fruit fly) [ 6, 7] that combines loss-of-function phenotypes with neuropharmacological techniques [ 8].
However, data cannot usually be exchanged between these tools without loss of information.
Some of these tools are loss leaders for Web sites that have products or services to sell.
RNAi is also a powerful genetic tool for loss-of-function studies.
RNAi is a widely adopted experimental tool for loss-of-function studies.
Against this backdrop CRISPR-based deletion holds great promise as a tool for loss-of-function studies in non-coding RNAs and genomic elements [ 5, 17– 20].
RNA interference (RNAi) is an invaluable tool for loss-of-function analysis in non-genetic organisms, and will be important to establish in this context.
The use of RNA interference (RNAi) mediated by siRNAs or short hairpin RNAs (shRNAs) for the silencing of specific genes has provided a powerful tool for loss-of-function studies.
