These significant genes were clustered by k-means clustering, then functionally classified in MapMan, a visualization tool for functional classification of Arabidopsis[ 41].
Hämäläinen, M. S. Magnetoencephalography: a tool for functional brain imaging.
Mori, T. et al. Inducible gene deletion in astroglia and radial glia--a valuable tool for functional and lineage analysis.
Ilmoniemi, R., Ruohonen, J. & Karhu, J. Transcranial magnetic stimulation — a new tool for functional imaging of the brain.
The protein sequence and functional information of DEGs were obtained from UniProt database73 or InterProScan tool for functional domain identification74.
The top three most used visualizations are the enrichment bar graph, enrichment network, and enrichment heatmap, highlighting the utility of the tool for functional enrichment analyses (Fig. 5b).
This technique has greatly contributed to the functional analysis of many genes in various organisms and has been established as an indispensable tool for functional genomics.
The CRISPR/Cas9 system has recently emerged as a powerful tool for functional genomic studies in Drosophila melanogaster.
RNA interference (RNAi) is a powerful tool for functional genetic studies in model organisms and mammalian cells.
Data were analyzed using the DAVID (the database for annotation, visualization and integrated discovery) bioinformatics tool for functional annotation49,50 and Cytoscape with the Enrichment Map plugin for visualization51,52.
Such pairwise correlated variability is thought to reflect direct or indirect synaptic connectivity or a shared common input and has been therefore used as a tool for functional segregation of neuronal populations36,37,38,39.
