Motif analysis was performed by using CisFinder tool (Developmental Genomics and Aging Section, Laboratory of Genetics, National Institute on Aging, NIH, Baltimore, MD, USA) [ 43] on 200-bp sequences centered at the expected binding site indicated by peak summit calculated using the MACS tool.
These USVs have been used as a diagnostic tool for developmental toxicity.
The Child Development Evaluation CDEE) test designed and validated in Mexico has been used as a screening tool for developmental problems in primary care facilities across Mexico.
Embryonic stem (ES) cells are an important tool in developmental biology, genomics, and transgenic methods, as well as in potential clinical applications such as gene therapy or tissue engineering.
Due to its non-invasive character and the detailed imaging within its resolution range, MR microscopy proves to be a valuable tool in developmental biology for the visualization of the inner architecture of rare and delicate museum specimens, such as the small dolphin embryo and fetus examined.
These data validate the power of ESC differentiation strategies as a model for mammalian development and, in combination with established genomic technologies, as a powerful gene discovery tool for developmental processes.
A construct validation study based on the N ref.sample confirmed the Norwegian ASQ version as an effective diagnostic tool of developmental delay [ 28].
As such multiscale mechanisms are practically impossible to understand intuitively, in recent years modeling and simulation has become a key tool in developmental biology (see, e.g., refs. [ 42– 42]).
Human pluripotent stem cells (hPSCs), namely, embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), with their ability of indefinite self-renewal and capability to differentiate into cell types derivatives of all three germ layers, represent a powerful research tool in developmental biology, for drug screening, disease modelling, and potentially cell replacement therapy.
The questionnaire included a screening tool for developmental problems, an assessment of the child's social competence, health care utilization and referrals, and maternal factors, including physical health, mental health, social support, parenting morale and sense of competence, and parenting support/resources.
It has been developed as a screening tool for developmental delay in infants in numerous paediatric populations with reported easy administration, short completion time, easy interpretation, sensitivity, measure of true positives, and specificity, measure of true negatives, varying, with most studies reporting higher accuracy in at risk populations [ 32, 44– 44].
