During the extended follow-up (HOPE-TOO trial), in those who were event-free at the end of the HOPE study, there was a trend toward a further reduction in major cardiovascular events [ 31].
Similar results were also obtained from the HOPE and the HOPE-TOO trials (The HOPE and HOPE-TOO Trial Investigators 2005), where a possible increased risk of heart failure was also hypothesized in the intervention group (vitamin E 400 IU daily).
Six subjects showed a high number of artefacts, which led to the exclusion of too many trials (> 20 trials, leading to < 40 trials per condition).
That might permit, too, the trial of the main war criminals, and not just their Bangladeshi collaborators.
Before the development of "due process," too many trials in the Western world were trials only in name.
There were too few trials to examine funnel plot asymmetry for evidence of small trial effects or publication bias.
A funnel plot for publication bias could not be performed because there were too few trials to analyze with the Egger test.
Unfortunately the DAS28 was reported in too few trials to fit a MTC model (DAS28 was only reported in 6 trials, not representing each of the treatments).
This is because there are too few trials and there are not enough people with the right skills to run trials.
We found, however, that more trials harmed the participants' ability to tell good from bad edges, suggesting that after too many trials the participants "ran out of ideas".
When too few trials are included in a meta-analysis, the χ test has little power to detect heterogeneity.
