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One reason for this could be that the locking scheme makes that residue too rigid in the cluster model.
Empirical and theoretical studies have both shown that there are certain DNA sequence patterns that are too rigid to form such loops [ 3].
Some blame a labour market that is too rigid to create sufficient jobs.
And the labour market is still too rigid, despite a useful bill that passed its first stage in parliament last month.
Republicans and administration officials said existing civil service rules were too rigid for an antiterrorism agency that had to respond quickly to an unforeseen panoply of threats.
They said that McLachlan is too "rigid in her introspection" and that they would like to hear her "work up a good head of steam".
Others, like James and Candace Mikulichji of San Bernardino, Calif., and Dennis Discher of Philadelphia, worried that the bishops' "zero tolerance" policy for abusive priests was too rigid, arguing that some priests should be allowed to continue with priestly work, as long as they did not work with children.
The court concluded that the former test used by the lower court was too rigid and that a case-by-case approach was more prudent.
That will help the IMF dispel concerns that it is too rigid in its ideology.There are also doubts about whether the IMF's instruments are quick and flexible enough for the full range of crises.
Later, Jones reveals, Hitchcock worried that he was too rigid in his commitment to narrative rigour.
With Michael Haneke I'd say it's the opposite - it's intense energy determined by a decision he made on his own in his little house in Austria.' Unsurprisingly, she describes her training at Paris' elitist National Conservatory of Dramatic Arts as painful - 'Painful in the sense that it was too rigid for me.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com