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"We're a medium-sized country and we can't afford to have too many variants of aircraft," said Bruno Rexecutivealcoz, executiviceice president for cooperation at Dassault.
Of the remaining sequences (49/206) not classified in the genealogy, 28 haplotypes from India and Indonesia (for example, 'outgroups' in Figure 1) had too many variants to be assigned; variation included many transversions (see Supplementary dataset 1).
Cost control, he says, is hopeless; products come in far too many variants, a misguided attempt to please the customer; and some companies have more than a year's production sitting in their warehouse.These habits are largely a legacy of the planned economy, in which success was measured by output, and a manager's biggest fear was to run out of parts and raw materials.
✘ Too many variants.
Second, the current IPv6 notation of "colon hexadecimal"[5] has another issue that there are too many variants of text representation for a single IPv6 address[6].
With the transition from IPv4 to IPv6, services running in Cloud computing will face problems associated with IPv6 addressing: the notation is too long (39 bytes), there are too many variants of a single IPv6 address and a potential conflict may exist with conventional http_URL notation caused by the use of the colon.
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Direct typing of the genetic variants that encode the HLA alleles is usually very difficult since most of these variants are surrounded by too many other variants that interfere with primer annealing.
Customers say these include a lack of mature development tools, too many Linux variants, acquisition costs for more sophisticated versions of the software and lack of applications for small and medium-sized businesses.
The problem is there are too many rare variants.
On the other hand, if the clustering is not aggressive enough, it can lead to too many false-positive variant calls.
Genome-wide association studies fail when they include too few accessions with functionally variant alleles, or if too many of the functionally variant alleles are distinct from each other.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com