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Too low concentrations will be limiting due to lacking cofactor molecules for TH.
On the other hand, too low concentrations, where less than 300 genes are deregulated, should be interpreted with caution.
On the other hand, critical genes may not yet be de-regulated at too low concentrations which might lead to false negatives.
Substandard medicines containing no or too low concentrations of the active ingredients, on the other hand, might be detected through clusters of reports on lack of efficacy.
Conversely, the use of too low concentrations of test compounds would result in false-negative responses and in the inability to identify any alterations of the transcriptome.
Too low concentrations of copper in culture media can lead to reduced cell concentrations and the accumulation of lactate, with no subsequent consumption of this metabolite.
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A too low concentration leads to the structure creation only at several 'hot' places randomly distributed on polymer surface.
The reason is probably a too low concentration of ethanol (61% w/w) in Avagard [ 7].
Too low concentration of potassium in the dialysate, diabetes mellitus, advanced age and dialysis performed after the weekend break are important factors that increase the risk of SCD [ 26, 29].
If the affinity of the antibody from a primary infection is too low (or is present in too low concentration) for a different serotype of Dengue virus, the virion is not neutralized and the secondary infection is enhanced (Guzman and Vazquez 2010; Heinz and Stiasny 2012).
This group included nine spots that contained peptides either at too low concentration or that exhibited adverse fragmentation behaviour resulting in poor spectra that were difficult to interpret, and 38 spots showing no significant homology to any protein in the database or that matched proteins of an unknown function.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com