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However, this was found to not be too deleterious, as it did not seem to affect the passage of migratory fish.
The role of large deletions is still a controversial subject, as Petrov (2002) found that small deletions are actually more common in small insect genomes, and suggested that large deletions are probably too deleterious to be common.
This makes sense as most effectors are multi-functional and have subtle effects on the host cell, which if left unchecked may become too deleterious, loosening the pathogen's grip on the host cell.
Only few intermediate s can become heterozygous but not homozygous, as they have to be close to the switch-like transition between 'can accumulate' and 'cannot accumulate' (see the 'wall of background selection' in Figure 1 and [ 7]) and their homozygous effects have to be too deleterious to accumulate.
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I can describe, without ever actually accomplishing it, how easily the moment, and the whole of the trip surrounding it, might be made into an instructive if all-too-familiar parable on the deeply fraught and too often deleterious nature of such well-meaning encounters between members of developed and developing countries.
Based on early estimates of the mutation rate in humans and the size of the human genome, simple calculations done decades ago showed that only a small fraction of it could be constrained at the sequence level, otherwise there would be too many deleterious mutations in every generation for the species to survive (Ohno 1972).
In low-foot shots, "there are too many deleterious things going on at once, you can't see what's going on," says Stephen Obenschain, head of the laser plasma branch of the plasma physics division at the Naval Research Laboratory in Washington, D.C.
Such speciation events can only be successful if the newly arising species has not accumulated too many deleterious mutations during its hybridogenetic history.
But the primary goal of Jefferson and other colonials in the national climate discussion was to scuttle the European notion that the New World's climate was too harsh and deleterious for settlement.
When too strong, these deleterious back-scattering effects can even prevent the correct operation of the Raman converter.
[Ca2+]i deprivation can be deleterious too as neurons depleted of Ca2+ can undergo death and activate the apoptotic machinery [103], [104].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com