The empire was governed by a small Parthian aristocracy, which successfully made use of the social organizations established by the Seleucids and which tolerated the development of vassal kingdoms.
And finally, we will not tolerate the development or use of weapons of mass destruction.
In patients with longstanding hypertension a systolic blood pressure of 200 mmHg or elevations in diastolic pressure up to 150 mmHg may be well tolerated without the development of hypertensive encephalopathy, whereas children or pregnant women may develop encephalopathy with a diastolic blood pressure of only 100 mmHg [ 17].
While this may reflect the lack of statistical power to detect a true difference, it is also possible that the maximum ventricular rate tolerated before the development of ventricular fibrosis and impaired LV function varies between individuals.
In a phase I clinical trial comprising 14 patients with progressive metastatic CRPC (some of whom previously also received chemotherapy or other investigational drugs), ipilimumab treatment at 3 mg/kg was well tolerated without the development of significant pathological autoimmunity [ 59].
Maternal physiology is adapted to tolerate and nurture the development of the fetus.
After excluding any infectious causes, the dose of colchicine was increased, but was not well tolerated, due to the development of diarrhoea, despite a lactose-free diet.
No cumulative toxicities emerged and cardiac dysfunction was uncommon, suggesting that the long-term trastuzumab treatment is well tolerated and that the development of trastuzumab-associated cardiac dysfunction is not determined by the duration of trastuzumab treatment or by the cumulative dose of the drug [ 22].
Current therapies for hepatitis C are based on poorly tolerated pegylated interferon, but the development of highly effective all oral regimes [ 5] provides an opportunity to eliminate the virus from many regions of the world.
Even as China's authoritarian government jails activists advocating such causes as human rights and Tibetan independence, the authorities have tolerated, albeit with troubling restrictions, the development of grassroots environmental organizations across China.
