And finally, we will not tolerate the development or use of weapons of mass destruction.
In patients with longstanding hypertension a systolic blood pressure of 200 mmHg or elevations in diastolic pressure up to 150 mmHg may be well tolerated without the development of hypertensive encephalopathy, whereas children or pregnant women may develop encephalopathy with a diastolic blood pressure of only 100 mmHg [ 17].
While this may reflect the lack of statistical power to detect a true difference, it is also possible that the maximum ventricular rate tolerated before the development of ventricular fibrosis and impaired LV function varies between individuals.
However, a 3-fold increase in the CYB-3 dosage, like the 2-fold increase (Tarailo-Graovac et al. 2010), is well tolerated throughout the development in the wild-type background.
In a phase I clinical trial comprising 14 patients with progressive metastatic CRPC (some of whom previously also received chemotherapy or other investigational drugs), ipilimumab treatment at 3 mg/kg was well tolerated without the development of significant pathological autoimmunity [ 59].
The patient tolerated the treatment without development of signs or symptoms suggestive of worsening LMD.
During the next 48 hours, 7 out of 8 extubated patients (88%) tolerated the spontaneous breathing without development of any of the criteria of weaning failure (extubation success), whereas 1 patient (number 12) met these criteria and was re-intubated (extubation failure).
Maternal physiology is adapted to tolerate and nurture the development of the fetus.
After excluding any infectious causes, the dose of colchicine was increased, but was not well tolerated, due to the development of diarrhoea, despite a lactose-free diet.
No cumulative toxicities emerged and cardiac dysfunction was uncommon, suggesting that the long-term trastuzumab treatment is well tolerated and that the development of trastuzumab-associated cardiac dysfunction is not determined by the duration of trastuzumab treatment or by the cumulative dose of the drug [ 22].
