At the recommended dose of temozolomide on Schedule A, 150 mg m−2 day−1 × 7 days every 2 weeks, peak plasma temozolomide concentrations and AUC0− t values would be expected to approach maximally tolerated values, and AGAT inactivation is rapid, marked, and sustained.
The SIFT algorithm assigns each possible substitution at a particular residue a "normalized" value such that if the substitution is completely tolerated the value is 1.0 and if not tolerated at all the value is 0. The sum of the 20 probabilities for each possible residue substitution was calculated, and the reciprocal of this sum was used as a measure of conservation.
'The Big Uneasy,' a recent article in the New Yorker, illustrates the illiberal and anti-democratic turn in college life; away from pluralism and genuine respect for difference and exploration of it towards the desire to impose a uniform ideology which does not tolerate value pluralism and the political and intellectual diversity it enables and sustains.
Although circumstances sometimes made accommodation to political liberalism necessary, fascists condemned this doctrine for placing the rights of the individual above the needs of the Volk, encouraging "divisiveness" (i.e., political pluralism), tolerating "decadent" values, and limiting the power of the state.
But the conservative Islamic forces that won power were unwilling to tolerate Western values, including open homosexuality.
Such prediction models should also tolerate missing values, which are common in clinical datasets.
For convenience, the API tolerates missing values and, in such a case, the average is returned by default.
Low soil-pH: most plants can tolerate pH values as low as pH 4, but only if the supply of nutrients is well balanced.
One of the limits in the fuzzy system therefore shifts more to the hypoventilated area and the system tolerates etCO2 values up to 60 mmHg as the normal state range.
Through these deliberations, many people have come to realize that organ transplant can be an acceptable and promising medical therapy so long as the donor's human rights are protected, and that the policy can protect the common good by tolerating divergent values and allowing individual choice of death criteria at the time of organ donation.
