As previously reported, ZOL was generally well tolerated; toxicities were similar in the two treatment groups, with no observed cases of nephrotoxicity resulting in dose modifications.
Therefore, although chemotherapy itself was well tolerated, toxicities such as malaise or fatigue, which the old JCOG toxicity criteria did not define, might have compromised the completion of chemotherapy before surgery.
In addition, a great number of genes encoding transcription factors (TFs) and molecular chaperones, e.g. HSF, MYB and HSP, were also up-regulated under As treatment, indicating gene regulation at transcriptional level is the key mechanism of P. notoginseng to tolerate toxicity of As.
Individuals without a known tissue or molecular high-risk factor for cancer will not tolerate toxicity that reduces quality of life.
The observed small study effect in the current analysis may also be due to such a true heterogeneity (Higgings, 2008), as a short-term benefit from chemotherapy is more likely in patients with high-performance status for tolerating toxicity of the treatment and such patients are more likely to be included in small, early phase clinical trials in the development of new treatment regimens.
Clinicians are more inclined to use all therapeutic options, such as combination chemotherapy and surgery in young patients than elderly ones because they are in better health and are more likely to tolerate toxicities associated with chemotherapy [ 10, 30, 31].
The treatment is rather well tolerated and toxicity is especially mild when a 3-week schedule is used.
The MuFRO1 mutant tolerated Fe toxicity in the vegetative stage and had 21-30% more grain Fe content than its wild type.
In conclusion, rice supplemented with SeVI tolerated As toxicity with reduced As accumulation and increased the nutrition quality by increasing EAAs.
The treatment was generally well tolerated and toxicity was acceptable.
