On the other hand, minor codons may be tolerated at sites in the translated mRNA where errors are less likely to affect the function or folding of the protein product, such as at evolutionary unconserved amino acid positions.
Ch Insp Nick Maton, of Dorset Police, said: "If we have an unauthorised encampment with no suitable alternative site to direct them to, we're in a position of either having to tolerate the site or to give them direction to leave, which purely moves the problem down the road".
Yet we Americans tolerate a site like Backpage.com that is regularly used to peddle children".
It was observed that a range of groups were tolerated at this site, and it was therefore anticipated that those examples incorporating polar functional groups would give more favourable values for c log P and thus proportionally higher values for LLE.
We suspect that Cys292 in the DECH-box motif might be needed, but since the protein did not tolerate the site-directed mutation we intended to construct, we were not able to test that hypothesis.
Wobble base pairs are often tolerated in target sites [44], [45].
Nonetheless, the chemical severities of changes tolerated at variable sites may be influenced by the codon's expected chemical severity.
It will be interesting to learn whether the loss of clathrin can be partially tolerated at these sites in mammalian cells as it can be in yeast.
Both treatments required a similar volume of HA soft tissue filler to achieve an equivalent efficacy, were well tolerated, and injection-site reactions were mild and transient in most cases.
Because the codon:anticodon duplex in the P site is not monitored so strictly as that in the A site, certain deviations from the canonical XXX of the slippery site are tolerated, including GGU, GUU, GGA and GAA [ 10, 12, 14].
