But government policy on selection remains a mess.David Blunkett, the education secretary, famously promised not to tolerate selection either by examination or interview.
In these cases, non-3n indels may not have significant effects in changing protein abundance, and thus may be tolerated by selection.
For Borges, the meaning of 'impossible' is not specified, but for biological organisms it is: Impossible is what cannot be tolerated by natural selection.
53 Therefore functional mutations in miRNAs are unlikely to be tolerated and negative selection may occur at these loci.
Like aging itself, menopause is tolerated by natural selection, because women (until recently) did not live long enough to experience it.
The (Bateson) Dobzhansky-Muller (BDM) model provided a solution to the paradox of how genetic changes that lead to speciation could be tolerated by natural selection despite decreasing the fitness potential of an organism.
Apparently for the single transcript gene the LRTS insertion either has not disrupted the host gene function or possibly provided some beneficial modulation of the initial function and thus has been tolerated by natural selection.
Because the function of such genes is important, any disruptive mutation in these genes can lead to severe and detectable disease phenotype and would not be tolerated by purifying selection.
"There is perhaps no arena of public life or governmental administration where racial discrimination is more widespread, apparent, and seemingly tolerated than in the selection of juries," wrote Bryan A. Stevenson, executive director of the Alabama-based Equal Justice Initiative, in a 2010 report.
This finding is consistent with Katti et al. [ 76] who showed that expansions of codon repeats corresponding to small hydrophilic amino acids are tolerated more, while strong selection pressures probably eliminate codon repeats encoding for hydrophobic and basic amino acids.
