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Drugability of the screened compounds showed tolerated results after being challenged to diverse physicochemical parameters.
EVP-6124, a selective agonist of the α-7 nicotinic acetylcholine receptor, has finished a phase 1/2 trial showing safe and well tolerated results and recently (Oct 2013) entered two phase 3 trials to test the cognitive benefits.
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We also concluded that antibodies with Fc-modifications for increased effector function may be less tolerated, resulting in toxicities at lower doses than those without such modifications.
In this retrospective cohort study, use of bolus IV enalaprilat was well tolerated, resulting in a substantial reduction in systolic BP with limited hypotension and no adverse effect on renal function when administered to hypertensive patients with AHF.
Early on, Takumi et al. showed that mutations in the C-terminal region of KCNE1 were poorly tolerated, resulting in a reduction in channel activity [38].
Currently, we can only speculate about possible causes but, our data imply that FMS patients were able to tolerate single painful stimuli well while repeated stimulation (i.e. during the experiment) were less tolerated resulting in reduced stimulation intensities.
LDX was generally well tolerated, resulting in typical stimulant AEs.
High doses of TPT are poorly tolerated, resulting in treatment delays or dose reductions.
In conclusion, gefitinib therapy, which was well tolerated, resulted in a CR in the brain of short duration.
Truncated substrates, while synthetically more accessible, are often poorly tolerated resulting in low conversion and exhibit loose stereochemical discrimination.
The incorporation of the more basic, NH-donor of piperazine 8 was not tolerated, resulting in a nearly 14-fold loss of activity.
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