For long-time fans, for whom the Red Bull ownership have been barely tolerated, referencing the corporate overlords as your tactical and stylistic cue was, well, like a red rag to a bull.
Where Child attempts an American voice with mixed results, Pullman fully embraces his English roots, which means children must tolerate references to everything from shillings to cricket without explanation.
In this analysis, we classified non-reference alleles with a "deleterious" predicted effect as "damaging", while "non-deleterious" or "tolerated" non-reference alleles were classified as "non-damaging".
Humans can theoretically tolerate this "reference dose" every day, risk-free, for a lifetime.
Parsed reads were then aligned locally to the reference sequence at HLA-A, HLA-B, or HLA-C using SSAHA2 (http://www.sanger.ac.uk/resources/software/ssaha2/) and output in SAM/BAM format [alignment parameters included: word hash size = 8, step size = 3, tolerated difference from reference = 10].
Both Test and Reference products were well tolerated, with no serious AEs and no relevant differences in safety profiles.
SIFT categorizes the non-reference mutations as "deleterious" or "tolerated".
The issues of lung overload and maximum tolerated doses have previously been discussed with reference to particle-induced carcinogenesis (Mauderly 1996; McConnell 1996).
Blacks have long felt that they are barely tolerated as political equals, and have seen every reference to "Southern heritage" as scarcely veiled nostalgia for the days of white supremacy.
Thus, consideration of boundary activities and boundary conditions tolerated by use during the design could allow the reference framework of the operational to be brought up to date.
