A well tolerated aerosolized formulation should be preservative free and not hyperosmolar, and have near-neutral pH and at least 30 mEq of permeant anion [27].
There was an expectation that its efficacy could be maintained (or even enhanced) with the better tolerated PLD formulation (Uziely et al, 1995).
The absence of skin irritation indicates that the prepared film was safe and well tolerated as transdermal formulation.
The 1.0% C31G co-polymer gel was the best tolerated, most acceptable formulation, and will be advanced to longer, more comprehensive trials.
All these suggest that BV-9238 has potential as a safe and well tolerated anti-inflammatory formulation for future use.
To assess the efficacy of a new, stable and well-tolerated formulation of scopolamine nasal spray the reproducible induction of whole body vibrations by a rotating chair was chosen and a validated seasickness score (SKS).
Future efforts should be focused on the development of a well-tolerated formulation, capable of inducing strong immune responses in patients with premalignant HPV-induced disease.
In addition, it was well tolerated in all formulations with no significant safety issues.
Our study suggests that the gel formulation tested is better tolerated than the corresponding liquid formulation.
This candidate malaria vaccine was well tolerated, but the vaccine formulation was poorly immunogenic.
