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These abiotic stresses, and the extent to which they can be avoided or tolerated due to ecophysiological adaptations that confer flooding tolerance, become increasingly growth limiting as water depth increases (Sorrell and Hawes 2010).
After 3 min of baseline measurements, followed by 3 min of unloaded pedaling, the work rate was increased every min by 20 W to the limit of tolerance (i.e. the point where the work rate could not be tolerated due to severe sensation of dyspnea, see Table 1).
Niacin (nicotinic acid) is the pharmacologic means of choice for decreasing elevated Lp(a) levels but the drug is often poorly tolerated due to adverse reactions.
Since Andrea Dworkin wrote about pornography as being anti-women in the early 1980s, we have become acclimatised to the idea that porn is bad for us, and must only be tolerated due to reasons of democracy and liberalism.
D-AmB was administered at the maximum tolerated dose of 1 mg/kg whereas M-AmB was given at the doses of 1, 2 and 3 mg/kg; doses were well tolerated due to their reduced toxicity.
While a simple aryl to alkyl switch was not tolerated due to differences in preferred amide conformation, heterocyclic amide isosteres with maintained aryl substitution improved potency and metabolic stability at the cost of physical properties.
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For many people with depression, however, ECT can be too difficult to tolerate due to side effects on memory and cognition.
GLP-1R agonists require injection, and are less well tolerated due principally to gastrointestinal adverse events (nausea, and less commonly diarrhea and vomiting).
Moreover, hypothermia and circulatory arrest increase drug toxicity and worsen adverse effects of drugs, even at doses that are normally well-tolerated, due to alterations in drug clearance and in drug response.
The low penetrance of Ppt1 phenotype indicates that the loss of Ppt1 is generally well tolerated perhaps due to the presence of compensatory mechanisms.
The authors found that a weekly frequency was not tolerated, mostly due to abdominal pain (Seymour et al, 2008).
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