Sentence examples for tolerated dosage from inspiring English sources

Compounds such as 5-benzylacyclouridine (BAU) [11] have been tested for their ability to increase the maximum tolerated dosage and therapeutic index of 5-FU through this uridine-mediated cyto-protective phenomenon [12].

The maximal tolerated dosage of OAC is likely to be lower for Chinese patients compared with Caucasian patients.

Thus, the maximum tolerated dosage has been reached, and the next lower dose – taxotere 75 mg/m2 and epirubicin 105 mg/m2 – will be used for further testing.

Patients who did not achieve the target with the maximum tolerated dosage of MTX started anti-TNF therapy in association with the ongoing medication, if not contraindicated.

Immediately following the double-blind phase of the study, open-label rivastigmine was flexibly titrated over a 12-week time period to a maximum tolerated dosage of up to 6 mg BID.

Backonja et al. investigated the effect of gabapentin monotherapy on pain associated with diabetic peripheral neuropathy by titrating from 900 to 3600 mg per day or maximum tolerated dosage or placebo [ 12].

Initially, we tested each drug over a broad range of physiologically relevant concentrations (1 100 μM) to determine tolerated dosages that also provided some improvement in cell survival.

5 Resistant hypertension is defined as a failure to achieve a BP goal of <140/90 mm Hg, despite treatment with a diuretic and ≥three different antihypertensive medication classes at maximally tolerated dosages.

With a standard dose of paclitaxel at 135 mg m−2, the dosage of irinotecan was escalated at four levels: 75, 100, 125 and 150 mg m−2; 125 mg m−2 was established as the maximum tolerated dose; this dosage was administered to 46 patients.

The goal of dose-finding studies is to find the highest tolerable dosage: the maximum tolerated dose (MTD) that corresponds to some given acceptable toxicity rate.

The maximum tolerated dose (MTD) was defined as the dosage of 5-FU that achieved 60% grade 3/4 toxicity.