Those who persist in fiddling with Shays-Meehan must be told by their constituents that voters will not tolerate changes that threaten the bill.
A key flashpoint was said to be the refusal of James, who reportedly had final say over the movie's dialogue, to tolerate changes by award-winning playwright Patrick Marber, who had been brought in to add colour to Kelly Marcel's script.
These results suggest that mammalian cells can sense, and do not tolerate, changes to the amount of Cdc45 that is available during the cell cycle.
However, the CLV3/WUS circuitry was also found to be surprisingly robust and to tolerate changes in CLV3 expression levels over a tenfold range [14], indicating that stem cells do not directly communicate their number via the amount of released CLV3 signal.
Collectively, these results suggest that leukemia cells have the inherent ability to tolerate changes in oxygen tension while maintaining an unaltered mitochondrial respiration.
By mutating this residue in modern IME2 we showed that, at least in some circumstances, the cell can readily tolerate changes that expand kinase specificity.
Genetic plasticity, as described on the manuscript, corresponds to the gene (or gene network) capacity to tolerate changes and the evolutionary plasticity, defined by Eq.1, is the record of changes a given gene family have experienced through its evolutionary history.
Indeed, modestly frequent amino acids (or under-represented amino acids in the proteins encoded by strongly expressed genes) may be under weaker selection, and for this reason, their codons may better tolerate changes driven by mutational bias.
Although the synchronization algorithm can tolerate changes in focus of the order of 50 μm in our particular optical configuration, the brightfield focus should ideally be maintained at a constant depth in the sample – especially when acquiring 3D datasets over several hundred μm – in order to maintain good synchronization.
