Many people cannot tolerate the fatigue and fuzziness it causes; some literally fall down, and my balance was seriously affected.
The ability to tolerate leg fatigue during CET and the ventilatory threshold, as a reflection of aerobic fitness, were independent predictors of the variation in endurance time to CET.
Therapy was generally well tolerated, with fatigue, fevers, and chills as the most common adverse events.
In general, avatrombopag was well tolerated; nausea, fatigue, and headache were most commonly reported.
Aprepitant appears to be well tolerated, with fatigue being the most commonly reported adverse event.
In these initial studies, the agent was well tolerated, and fatigue was the dose-limiting side effect (Raymond et al, 2003).
Overall, vorinostat appears to be generally well tolerated, with fatigue and gastrointestinal symptoms being the most common side effects at lower doses and thrombocytopenia at higher doses.
A phase I trial of tivantinib in 51 patients with solid tumours (including two patients with breast cancer) found the inhibitor to be well tolerated, with fatigue, nausea and vomiting being the most common adverse effects [ 90].
Since inclusion of all genotypes was allowed, 4 patients (50%) were infected with genotype 1, 2 (25%) with genotype 4 and 2 (25%) with genotype 3. Treatment with either GS-9450 or placebo was generally well tolerated with fatigue, headache and nausea being the most reported side-effects.> -wrap-foot> notnot applicable The efficacy of 10 mg of GS-9450 wastudieded in a 14-day dosing trial.
The bearing surfaces must be made of materials to tolerate loading without fatigue or fracture, minimize friction, have superior wear characteristics, and minimize the generation of wear debris [ 8].
