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Those who persist in fiddling with Shays-Meehan must be told by their constituents that voters will not tolerate changes that threaten the bill.
By mutating this residue in modern IME2 we showed that, at least in some circumstances, the cell can readily tolerate changes that expand kinase specificity.
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Sequence changes altering the equilibrium of the conformational ensemble, and causing a loss of a subset of promiscuous functions, may be better tolerated than sequence changes that cause a protein to lose its entire function due to misfolding.
This is not the case, however, for the less abundant Qrrs 1, 2, and 3. We conclude that there is an upper limit to the extent to which the quorum-sensing cascade can tolerate and compensate for changes that deplete the Qrr sRNA pool in V. cholerae.
Accompanying the dietary change — and probably evolving along with it — were behavior changes that allowed dogs to tolerate living near people and ultimately being adopted by them.
They found that the vaccine was well tolerated and also appeared to produce antigen-specific immune changes that stopped the destruction of myelin.
Evolvability is achieved by increasing the capacity to tolerate non-lethal phenotypic changes, which are exposed to selection, and not just non-lethal genotypic changes that aren't.
These results suggest that mammalian cells can sense, and do not tolerate, changes to the amount of Cdc45 that is available during the cell cycle.
At one extreme, zero variance CAGpolyQ repeats – those that do not tolerate changes in Q-tract length – can likely be excluded as candidates for polyglutamine expansion disorders.
This supports that genes in the downstream part are freer to tolerate changes, and show more differentiation among populations.
Ultimately, preferences about objectives and about the level of change that is tolerated exert a strong influence on the assessment of the vulnerability to risk and the subsequent deduction of management responses (Seidl and Lexer 2013).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com