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The full cleavage profiles for each position are provided in Figure S6 of the Supporting Information, with select examples of a restrictive and tolerant position shown in Figure 3. Restrictive positions, such as P1 (A90), tolerate only a few mutations, while permissive positions, such as P4 (R87), tolerated all amino acids, although to varying degrees.
In all this, Larrimore maintains a supremely tolerant position.
Bush tries to walk the fine line between Republican troglodytes who oppose all immigration reform, and the obvious necessity for a more tolerant position.
He decried the attempt to "remove certain ideas from a broader debate" and mused that an audience's offended reaction to an idea might "prompt further reflection, leading to a more reasoned, more tolerant position".
Following the Conservative election victory in 2010, the current education secretary and cabinet allies such as George Osborne were unimpressed with Prevent's adoption of a more tolerant position, and particularly disapproving of the fact that controversial groups received government funding.
Representative data from one highly restrictive (P1) position and one tolerant position (P4) are presented in panels C and D of Figure 3, with kinetic plots for all cleavable variants shown in Figure S7 of the Supporting Information.
Similar(54)
TILLING: Targeting Induced Local Lesions in Genome; COMT1: Caffeic acid O-methyltransferase 1; 4-coumarate-CoAte-CoA ligase 1; HCT2: Hydroxycinnamoyl-CoA:shikimate/quinate hydroxycinnamoyltranshikimate/quinatethydroxycinnamoyltransferaseT: Sorting Intolerant From Tolerant; PSSM: Position specific scoring matrix.
New Orleans is a tolerant place.
It's a tolerant place".
This is because it is very difficult to be tolerant of positions taken for purely ideological reasons.
SIFT (Sorting Intolerant from Tolerant) showed positions of amino acids and the single letter code of amino acids that can be tolerated or deleterious for each position.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com