However, the use of CpG (10 μg/ml) for preactivating TLR9 failed to induce any trained or tolerant effect (Fig. 2C).
Avila and colleagues [ 94] found that animals chronically treated with morphine became tolerant to its effects on the hypothalamic-pituitary-adrenal axis, and to its effects on T-lymphocyte proliferation.
Sometimes like a drug, we need more and more of it for the same result as we desensitise or become tolerant to its effects, so it will never really gives us we we want, or what we need.
Regulators and doctors tend to be less tolerant of side effects in quality-of-life drugs than they are in medicines intended to mitigate life-and-death diseases.
Whether in "non-tolerant" or "tolerant" groups, the effects of morphine were stronger in "obex-transected" than in "sham-operated" animals.
The results also indicate that the fishP is tolerant to gene effects characterized with different types of SNP associations.
Based on clinical experience, it is possible that prior tamoxifen users who perceived that they had adequate hormonal therapy were therefore less tolerant of side effects of AIs.
Killifish resident to these sites are dramatically tolerant to the effects of PCB126, displaying LC20 values ranging from ~400 to ~ 8000 times higher than those for the sensitive killifish (Table 1).
Antibiotics do not kill the organisms that produce them since they have co-evolved systems that make them resistant or tolerant to their effects, but it is when similar systems develop in the target pathogenic bacteria allowing them to survive antibiotic treatments that major problems arise.
Plants become tolerant to the effects of freezing through the acclimation process or hardening, i.e. a relatively slow, adaptive response during late autumn, signalled by a gradual decrease in temperature, day length and light intensity leading to a series of biochemical changes enhancing the cold resistance of sensitive tissues.
To counter this effect, tolerant strains can shift the composition of the fatty acids in their membrane to block the entry of solvents.
