Sentence examples for tolerance regulatory from inspiring English sources

Since PP2B is a crucial signaling molecule in regulating adaptive immunity [52] a potential inhibitory effect of axotrophin on PP2B activity may present an immune tolerance regulatory mechanism in addition to LIF receptor downregulation.

Both agents might have difficulty passing regulatory review in a zero-tolerance regulatory atmosphere.

Treatment with a cocktail of CD4 and CD8-specific monoclonal antibodies (mAb) induces long-term transplantation tolerance and regulatory CD4+ T cells that induce tolerance in non-tolerant T cells.

There is no tolerance, either regulatory or in public perception, for a human gene-based pharmaceutical to end up in the world's food supply".

A related approach will be clinical studies to induce allogeneic or xenogeneic tolerance using regulatory T cells in solid organ transplantation.

The justification of this work inspired by the significant and active research interest over the last decade in the use of produced water as a resource in reinjection as alternative secondary and tertiary recovery method could achieve the goals of the zero tolerance by regulatory authority to water disposal management to maintain marine life and environment sustainability.

Moreover, considering that activation rather than presence of autoreactive T cells is the hallmark of autoimmune disease, the creation of an environment resulting in failure of tolerance and regulatory mechanisms, rather than emergence of novel microbial antigenic determinants, may well be at the root of autoimmunity.

IL-2 also plays an essential and non-redundant role in the control of peripheral T cell tolerance by regulatory T cells (reviewed in [4] [6]).

Most recently, in a murine model of transplantation tolerance, donor regulatory T (Treg) cells contained within transferred blood products were found to induce naive host T cells to adopt a Treg phenotype [11].

This approach has the ability to improve several of the phenotypes related to pentose utilization, including high sugar tolerance and regulatory issues.

Thus, by initially (day 14) activating TGF-β in macrophages, while keeping IL-6 at bay, type I IFN may favor TGF-β-dependent tolerance by regulatory T cells while preventing activation of TGF-β+ IL-6=induced Th17 differentiation.