HipA encodes a serine-protein kinase, the multidrug tolerance activity of which is neutralized by binding to the transcriptional regulator HipB and hipBA promoter.
We previously used an autoantibody transgenic mouse reporter system to examine the effect of different autoimmune backgrounds on B-cell tolerance, failure of which is a fundamental defect in lupus.
There are several mechanisms for the maintenance of peripheral tolerance, one of which is when external stimuli reprogramme DCs towards a less activated tolerogenic cell type.
Frailty in that study was defined, in part, by slowness of gait and low exercise tolerance, both of which characterize lower-limb muscle weakness.
The patients with RA, compared with healthy control individuals, had lower mechanical pain thresholds, lower heat pain thresholds, and lower cold pain tolerance, all of which are expected in a situation with peripheral sensitization to noxious stimuli [ 2].
Previous research have identified several key amino acids affecting the glucose-tolerance, most of which are located at the substrate entrance site [ 35, 37].
"The school does not promote adequately students' awareness and tolerance of communities which are different to their own.
"The very existence of the law creates a climate of tolerance of prejudice, which leads to real physical harm and fear.
Given this analysis, the legal and cultural tolerance of pornography, which makes the subordination of women sexually appealing to men, is immoral.
It was demonstrated that LCM was able to induce the highest stress response and stress tolerance of cells, which was adapted during culture, while SCM failed.
