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The PMT based case study demonstrated the effectiveness of our simulation based approach and the PMT model by clearly identifying the fragility of product based design processes and the tolerance of function based design processes to overload situations.
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This paper presents a method for robust tolerance design of function generation mechanisms with joint clearances.
Importantly, no tolerance of CB1R function and behavioural responses takes place after chronic FAAH inactivation (Ahn et al. 2009, Schlosburg et al. 2010).
Only rapeseed and wheat collections carry a higher density of mutations, as expected from their polyploid nature and consequently, their higher tolerance to loss-of-function mutations due to gene duplications and redundancies (Table 3).
According to the World Health Organization, injuries include lesions from acute exposure to energy exceeding the threshold of physiological tolerance and/or impairment of function resulting from a lack of one or more vital elements (i.e. air, water, warmth), as in strangulation, drowning or freezing [ 1].
In Arabidopsis, over-expression of AtPP2CG1 increased salt tolerance, whereas its loss of function impaired salt tolerance [ 10].
This parameter sets the tolerance of the activation function to large input values, the larger this value is the less sensitive the activation function becomes.
In a previous study, RAGE was demonstrated to continuously improve acetic acid tolerance by accumulating reduction-of-function modifications in the genome [ 19].
Functional analysis of the GABA-T encoding gene POP2 revealed that it constituted a determinant of salt tolerance since the loss-of-function pop2-1 mutant was shown to be oversensitive to ionic stress in spite of higher GABA levels in its tissues suggesting that GABA itself was not associated with tolerance.
First, we explored the dependence of tolerance as a function of duration of exposure to the toxicant.
MAQ allows efficient integration over the entire integration domain and requires only an error tolerance and maximum number of function evaluations to be specified.
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