For instance, the prototype BVMO, cyclohexanone monooxygenase, loses dramatically its activity when it is incubated with 5% of solvents and its tolerance is very poor, since after 20 min incubation with 5% methanol the enzyme is completely inactivated (Secundo 2011).
Before concluding that a triptan is ineffective, it is recommended that it is tested over at least three attacks, except if there is poor tolerance (grade A methodology).
Tolerance of endotracheal aspiration is poor and reported to constitute one of the most painful maneuvers in critically ill patients [3], and administration of analgesia, with or without sedatives, prior to the maneuver has been advocated [2].
Indeed, the recent position statement mentioned above states that in selected older patients not at target or where there is poor tolerance to glucose-lowering agents, the use of DPP-4 inhibitors can be considered as second-line therapy [ 69].
However, the relationship between tolerances at the two stages is poor, suggesting that they are regulated by different processes and genes (Singh and Flowers 2010; Hossain et al. 2015; Rahman et al. 2016; Ahmadizadeh et al. 2016).
One flaw that the system might harbor is poor fault-tolerance.
As outlined above, tolerance is expected to be poor whenever the decline in PNa levels outpaces the compensatory mechanisms.
When used for long periods in the treatment of infected non-unions, there is poor patient compliance and tolerance.
Tolerance is a pretty poor substitute, as it turns out, for real love and understanding.
However, the toxicity profiles differ and switching from one regimen to the other for poor tolerance is a reasonable option.
