Yet none has examined associations between these biomarkers and OSA in relatively healthy adults across a range of glucose tolerances from normal to prediabetes and diabetes while controlling for the degree of obesity.
CFRD is part of a continuum of glucose tolerance abnormalities, ranging from normal glucose tolerance (NGT), to impaired glucose tolerance (IGT), to CFRD without fasting hyperglycemia (CFRD FH−), to CFRD with fasting hyperglycemia (CFRD FH+) (Fig. 1).
To distinguish curve trajectories reflecting deviating glucose tolerance from those considered normal, the information from FPC2 and FPC3 was necessary.
Fifty-one subjects (10,7 %) worsened from normal glucose tolerance to impaired glucose tolerance.
Furthermore, the progression from normal glucose tolerance to impaired glucose tolerance and T2D is associated with declining insulin secretion.
After the progression from normal glucose tolerance to abnormal glucose tolerance, postprandial blood glucose levels increase initially.
Thus, parasympathetic tone may decline with an autonomic imbalance shifting toward augmented sympathetic tone during the development from normal glucose tolerance to impaired glucose tolerance and finally diabetes [ 7].
In addition, we evaluated the performance of traditional lipid ratios, apo B/apo A-I ratio, VAI, LAP, and TyG in correlating with IR across the full glycemic spectrum (from normal glucose tolerance to impaired glucose tolerance to diabetes).
The natural history of T2DM has been well defined [ 10- 14], starting with a genetic predisposition and progression from normal glucose tolerance with insulin resistance to impaired glucose tolerance with superimposition of beta cell failure on insulin resistance, and eventually to overt T2DM characterized by severe beta cell failure and insulin resistance.
Impaired fasting glucose (IFG) was introduced in 1997 by the American Diabetes Association (ADA) (1), and, analogous with impaired glucose tolerance (IGT), it was meant to represent an intermediate stage in the transition from normal glucose tolerance (NGT) to overt type 2 diabetes.
