Although best practice guidelines point out that moderate to severe depression should be approached with pharmacotherapy together with complementary therapies, the use of antidepressant drugs in older adults has various disadvantages, such as long response time, side effects, potential risk of dependency and tolerance, poor compliance rates and high probability of drug interactions.
The relatively poor outcome in adult ALL has been explained by an increased frequency of high-risk molecular subtypes with more aggressive clinical behavior and greater drug resistance, poorer tolerance and compliance with treatment, and less effective treatment regimens compared with childhood ALL [6], [8], [9].
Patient tolerance and compliance were both found to be excellent.
This will include recording which medications, time of starting medication, timing and results of DEXA scan and tolerance and compliance with their treatment at each follow-up stage.
The study co-ordinator monitors participants' drug tolerance and compliance weekly for the first 5 weeks, and then every 28 days for the remaining 21 months.
Previous reports have found higher technical success rates achieved under deep sedation and general anesthesia than moderate ("conscious") sedation because of better patient tolerance and compliance [ 27, 28].
Maximal medical treatment was defined as therapeutic trials of the medication listed in table 1, based on the tolerance and compliance of each patient.
Also, the presence of a systemic inflammatory response and the associated nutritional decline may influences tolerance and compliance with active treatment [ 25, 26].
Some drugs have low tolerance, low compliance, or more adverse effects while prolonging PFS or OS, but efficacy measures can't capture these aspects.
Once daily dose administration with promising oral capsule formulations should lead to fewer adverse effects, better tolerance and compliance, without reduction in paclitaxel exposure and efficacy against solid malignancies.
