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Instead of learning to discriminate between known functional variants and controls, CADD uses a training set composed of variants that have become fixed in the human lineage, and which therefore presumably represent tolerable variation, and simulated variants that are not observed in human populations.
The enormous complexity of the auditory system suggests elaborate gene interactions may render it vulnerable to accumulation of deleterious variants otherwise tolerable in the context of a neutral genetic environment.
Possible pathogenic effects inferred using Polyphen and SIFT, predicted the variant to be benign and tolerable.
This is an interesting class of variant as, whereas some substitutions appear to be tolerable and the underlying variants are common polymorphisms, others have been implicated in a range of genetic diseases such as cystic fibrosis, muscular dystrophy and sickle cell anemia [ 3].
That said, the percentage of flagged variants and genotype-call error rates were still quite tolerable with read depths of 10 or more and moderate sample sizes, even in the presence of substantial excess heterozygosity.
Legoland had been tolerable.
That much was tolerable.
Still, adequate is tolerable.
NOISE LEVEL -- Tolerable.
It was tolerable.
It is not tolerable.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com