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Phase I studies conducted in stable renal transplant patients maintained on a cyclosporine (CsA -based regimen have revealed a tolerable profile of FTY720 for transplant pharmaCsA -based
The more tolerable profile of zofenopril is coupled with an equivalent or even better efficacy than ramipril in the prevention and treatment of cardiovascular diseases, as evidenced by several head-to-head trials [ 26- 28].
Similar(58)
The phase II clinical trial demonstrated potent antitumor activity and tolerable toxicity profile by mogamulizumab monotherapy (Ishida et al., 2012), which led to approval by the regulatory authority in Japan in 2012.
Long-term data from the PKUDOS registry suggest that sapropterin has a tolerable safety profile and that continuous use is associated with a significant and persistent decrease in blood Phe and improvements in dietary Phe tolerance.
The IDO regimen demonstrated a tolerable toxicity profile in the present trial.
A remarkable median overall survival of 13.5 months was reached, with a tolerable toxicity profile.
In conclusion, pemetrexed with FA/VB12 resulted in a tolerable toxicity profile.
In addition to a tolerable safety profile, evidence of biologic effects and efficacy were demonstrated.
Both doses showed antitumor activity, and 75 mg generally resulted in a tolerable safety profile.
Excellent local control with tolerable toxicity profile has been consistently reported [ 1].
In summary, this study demonstrates that temsirolimus enables disease stabilization with tolerable toxicity profile among HCC patients.
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