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Non-inferiority margins must be chosen in a manner that considers both the uncertainty associated with the estimated treatment benefit and a tolerable margin for similarity between the tested and established therapy.
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Tolerable margins of random error in DSS data may exceed 20%.
Nevertheless, rotational movement is kept within tolerable margins, as may be judged with respect to the resulting deck deflections.
The random introduction of errors and missing data in key parameters in a large 'gold standard' dataset had little noticeable affect on population and mortality profiles, demonstrating a high level of robustness of DSS data and tolerable margins of error that may exceed 20%.
In pork production, the deterrents to entry from slim margins to environmental restrictions are daunting.For Smithfield itself, the low margins are tolerable as long as there are prospects for revenue growth, whether through innovation or through acquisitions as struggling competitors bail out.
Our findings suggest a relatively small safety margin between the established tolerable Cd reference exposure of 62 µg/day and exposure levels previously associated with evidence of kidney and bone effects in Mae Sot residents, where dietary Cd exposures among women were only 1.6 2.1 times the reference value.
Let M be the non-inferiority margin, that is, the maximum tolerable amount by which λE can be worse than λS (M>1).
On rangelands, soil, nutrients and water are scarce and only narrow margins of resource losses are tolerable before crossing the sustainability threshold.
Regardless which value is considered the margin between weekly intake of Cd from food and the tolerable intake might be small for certain subgroups of the population, e.g., children or vegetarians.
They attached a 0.5- to 1-cm margin to contrast-enhancing lesions, and the toxicity profiles were reportedly tolerable, while the proportion of radiation necrosis in extended-field SRS seemed to be higher than with conventional SRS, approaching a significant level.
The corresponding European Commission tolerable daily intake (TDI; 10 μg/kg/day) is based on the assumption of a 500-fold safety margin over the no observed effect level (NOEL) dose derived from three-generation rat reproductive toxicity trials (EC Scientific Committee on Food 2002).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com