Although subsequent studies, using sequential short deletion mutants between E13 and T21 of p6gag, as well as a long fragment deletion mutant (S14 I31 of p6gag), suggested that these mutations had relatively tolerable effects on Gag processing and in vitro viral infectivity, the influences of deletion between P30 Y36 of p6gag, as observed in CRF07_BC in Taiwan, were not addressed.
If your reaction to soy is mild, you may be able to consume soy products in small quantities with tolerable effects, especially with the help of oral antihistamines.
If Adv 36 is found to be a cause, research is needed to identify effective antiviral agents with a more tolerable side effect profile.
Some adverse effects, particularly dry mouth and drowsiness, were more likely with tricyclics, although this did not result in significantly greater dropout rates, implying a tolerable side effect profile given the benefit.
A growing number of studies on the effects of HCA, both in experimental models and in patients, indicate that instead of being a tolerable adverse effect, HCA may exert direct protective actions and may be therapeutic by itself [ 1].
In addition, the AIs demonstrate a tolerable side effect profile in comparison with tamoxifen, and this has led to their early incorporation as standard of care therapy.
46 While the adverse effects from cytotoxic chemotherapy preclude treatment for many elderly patients, new classes of agents under development may offer a more tolerable side effect profile.
It is contraindicated in patients with heart failure but is safe in the elderly and diabetic patients and has a tolerable side effect profile.
Given afatinib's activity, overall safety, and tolerable side effect profile, afatinib was FDA approved for first-line treatment of these cancers (Dungo and Keating, 2013).
Hypercapnic acidosis (HCA) that accompanies lung-protective ventilation may be considered permissive (a tolerable side effect), or it may be therapeutic by itself.
With their ease of use, tolerable side effect profile, and good efficacy, the depot formulations have gained wide acceptance from both patients and the medical community alike.
