When no statin is tolerated or the maximal tolerable dose of statins fails to reduce LDL cholesterol to target levels, nonstatin therapies should be used.
Patients unable to tolerate a dose had their dosage reduced to the previous tolerable dose.
Patients who do not tolerate up-titration to 1.8 mg liraglutide will remain on the highest tolerable dose of liraglutide.
The maximal tolerable dose (MTD) is defined as the dose above which we are causing intolerable side effects.
But while doctors now generally use the maximum tolerable dose of each drug, Celator says the ratio of the drugs is what matters more.
This study will also determine the highest tolerable dose that can be given and whether it causes your cancer to shrink or remain stable.
The liver is an organ with a parallel architecture, so the average tolerable dose in the whole liver should be considered rather than the maximum tolerable dose at one point.
Only if patients reach the maximum tolerable dose of statins, or face unbearable side effects, should they try Vytorin.
Dose-limiting toxicity was organ toxicity owing to graft-versus-host disease, and the maximum tolerable dose was 5 mg.
Today, probably the research with the highest risk and lowest benefit to participants is Phase I cancer research, which tests experimental cancer drugs to determine the highest tolerable dose for subsequent studies.
In vitro cytotoxicity studies reveal that tolerable dose rate for these particles can be significantly high and particles are non-toxic in nature.
