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In an earlier safety evaluation, PBE showed excellent overall tolerability without any side effects.
Furthermore, vildagliptin treatment was associated with good tolerability, especially GI tolerability without hypoglycaemia.
Therefore, an NVP-AUY922 intermittent dosing regimen gives optimal tolerability without significantly affecting efficacy.
First, both dolutegravir and rilpivirine have excellent tolerability, without the bone or renal toxicities of TDF or the neuropsychiatric side effects of efavirenz.
This dose was determined by the safety committee to have a high probability of acceptable tolerability without a separate dose escalation study.
In patients with refractory solid tumours, a phase I trial of angiozyme demonstrated [ 110] good tolerability without significant side effects, and phase II trials are ongoing.
Similar(47)
The studies reviewed here demonstrate that ingenol mebutate gel is highly efficacious, has a good tolerability profile without systemic bioavailability, and is associated with near-absolute treatment adherence in clinical studies.
Therefore, there is enormous need to improve tolerability of chemotherapy without loss of efficacy.
Canakinumab significantly reduces systemic high-sensitivity C-reactive protein (hsCRP), IL-6 and other inflammatory biomarker levels without tolerability issues [ 15, 17- 19].
The 200 µg dose of quinagolide was the most effective in preventing moderate/severe early OHSS, but this dose was associated with poor tolerability when administered without dose-titration.
"NIA-114 provides many of the benefits of retinoic acid without those tolerability issues," Myron Jacobson said.
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