The LOCF (N = 271) yielded very good tolerability for 57.2%, good tolerability for 36.5%, satisfactory tolerability for 5.5%, and not satisfactory tolerability for 0.7% of patients.
Poor tolerability for current acute or preventive treatments.
NNH showed substantial differences among treatments, with higher numbers indicating better tolerability for erenumab.
Mirabegron, a β3-adrenoceptor agonist, has demonstrated efficacy and tolerability for up to 12 wk in phase 3 trials.
PRISM II evaluated DM/Q effectiveness, safety, and tolerability for PBA following stroke, dementia, or traumatic brain injury (TBI).
Mechanical performance test for the 2ST cooler units proves tolerability for pyro shock and vibration environment of the Astro-H criteria.
Literature reports four studies (two open trials, and two randomized and controlled) about riboflavin high doses (400 mg/day) that suggest its efficacy and tolerability for preventing migraine in adults [9 12].
Two patients assumed one treatment and eight subjects assumed two treatments; so the ITT population was of 92 cases and were evaluated for efficacy and tolerability for both the treatments.
The aim of this study was to develop a new class of antibody-drug conjugates (ADCs) with the potential to not only enhance treatment efficacy but also improve tolerability for patients with B-cell lymphomas.
The COMPEL Study provides clinical evidence for consistency of the efficacy and long-term safety and tolerability for onabotulinumtoxinA for the prevention of headache in those with CM who have been treated every 12 weeks over 2 years (9 treatment cycles) with the fixed-site, fixed-dose injection paradigm.
Future use of SERMs may also include their use in a tissue selective estrogen complex (TSEC), a therapy that combines a SERM with estrogen(s), designed to deliver the efficacy of each component with improved overall tolerability for the treatment of postmenopausal women.
