The modeling experiments presented here confirm the finding that a group of model structures able to achieve a cut-out or toggle switch behavior explains the available data.
Depending on the strength of the necessary positive feedback one can distinguish between (irreversible) "one-way switch" or (reversible) "toggle-switch" type behavior.
Simulations based on the kinetic models of these systems [ 24, 16] (see details of the equations in the METHOD) confirm the on/off and toggle-like switching behavior in their response curve and state space.
Procedures for conducting measurements of oscillatory behavior and toggle switch behavior of these synthetic genetic devices are described.
Components of the Lac and Ntr systems were used to construct genetic circuits that display toggle switch or oscillatory behavior.
Atkinson, M. R., Savageau, M. A., Myers, J. T. & Ninfa, A. J. Development of genetic circuitry exhibiting toggle switch or oscillatory behavior in Escherichia coli.
Atkinson, M.R., Savageau, M.A., Myers, J.T. & Ninfa, A.J. Development of genetic circuitry exhibiting toggle switch or oscillatory behavior in Escherichia coli.
People toggle effortlessly between these behaviors every day, because people are astute readers of context.
Therefore, to design thermally aware multi-tier FPGAs, there is a need to first understand the relationship among circuit architectures, toggle rates, layout, clock frequency, I/O behavior, power, temperature, thermal stress, and thickness of inter-die substrates.
Another motivation is to make comparison between external noise-induced behaviors in the single toggle switch system and in an ensemble of toggle switch systems aforementioned.
