It presents its ontology that, together with methodology, epistemology and axiology, constitutes a formal definition of a scientific field.
However, only a few papers have considered quantitative and qualitative factors together with imprecise methodologies.
In this paper, which is the first of two parts, the feature creation and validation methods are presented together with the methodologies for operation and tool selection.
These approaches, together with new methodologies such as conditional linkage analysis, generalized family-based association tests (PDT), and a new generation of genetic markers (SNPs), opens the door for additional AD gene discovery.
Beyond the treatment of current patients, Al-Shahrour is helping to develop a database of novel mutations and their associations to drug responses, together with computational methodologies, that could help predict drug responses in future patients.
One can envisage a scenario where, by using such a personalised CLL xenograft model, together with new methodologies such as next generation sequencing and single cell analysis, the best combination of compounds targeting different CLL subclones can be easily designed.
Experimental results are presented together with the methodology developed to classify ash granulometry.
The benefits and challenges involved in this analysis since an early phase of the design are discussed together with the methodology pursued.
Simulations are performed using an immersed boundary method, together with the methodology developed in our earlier work for accurate prediction of gas solid interactions at relatively low grid resolutions.
